Episode 162: Dave Asprey: Host Elle Russ chats with The Bulletproof Exec himself, Dave Asprey, about his new book, Head Strong, which helps people boost cognitive function, optimize brain health, and eliminate the dietary and environmental triggers bringing us down.
“I have worked in pharmaceutical safety for six years, and am involved in clinical trials every day. The following is my personal opinion and does not necessarily reflect the opinion of my employer.
I’d just like to clarify the point about study discontinuation, since Mark points this out as a key smoking gun here. Many drugs are now tested for so called MACE (major adverse cardiac events) events – this is particularly true with diabetes drugs but is often seen with other classes including CV drugs. This really became more common after Avandia and the discovery of unintended CV events. Cardiovascular outcomes trials are almost always results-based and do not have well-defined timelines. That is, they go until they reach enough MACE events to draw statistical significance, then stop. Drug companies will have some idea of how long this should take, based on their knowledge of patients with this disease. Without seeing the protocol I don’t know about the timelines here, but I would expect that they reached their endpoints early. Clinical trials are massively expensive and companies aren’t going to keep running a trial once they get to a level where data is statistically significant.
Ending a study early doesn’t necessarily indicate poor outcomes related to study drug. It could mean that they have reached the designated number of endpoints in the control group. More importantly, it could actually indicate that their treatment is so effective that it’s unethical to keep giving patients a placebo or comparator. This happened with a cancer drug that I was working on – it was so clear that the drug was extending lives that FDA didn’t feel it was ethical to withhold the treatment from the other group. I doubt that’s what happened here, but it does happen and ending a study early isn’t damning on its own. In fact, Amgen is about to enroll on a long term, open label extension of this study to examine potential adverse events, so I highly doubt that this was stopped early due to safety concerns.
Otherwise, I agree with you that it didn’t improve mortality and therefore is not a huge deal. Wall Street also agreed, and Amgen stock took a hit, even with positive results.”
– Important insight from an insider. Thank, wildrover.
Do you ever follow a weekend of dining out with a strong craving for vegetables? That’s where my head (and stomach) is at this week while meal planning. This past weekend we ate a ton; we had my husband’s family over for barbecue and ate so much cake (not to celebrate — I had leftovers from recipe testing). Plus my work week ahead is filled with testing more cakes, a trifle or two, cheesecake, two types of cookies, a pie, and five no-bake desserts.
I need some vegetables to balance all the revelry, ya’ll!
Of course, I still need recipes to satisfy my two young kiddos and accommodate my husband’s erratic work schedule. So with that in mind, here are five vegetable-centric recipes to balance the week ahead.
When you’ve got a family to feed — or just a serious Costco habit — the idea of having some more space in the freezer is incredibly appealing. You can just imagine the benefits: You’ll do less grocery shopping because you can buy so much meat at once and freeze it for the future, you’ll spend less money because you can take advantage of sales and stick the excess in the freezer, and you’ll avoid last-minute pizza by freezing more meals for future late nights. You can also make sure you never run out of ice (for cocktails!) or ice cream (both of which are very important!).
Of course, investing time, space, and money into a standalone freezer isn’t something you should do without adequate thought. Take this quiz to see if you really need one.
Homemade cinnamon rolls never seem like a project you can undertake in the morning and have ready in time for breakfast, right? All those ingredients to measure out, kneading in a stand mixer, and of course, two rises for the yeast to do its thing. It’s no wonder we’re also picking them up from a bakery, IKEA, and even that chain in the mall.
What if I told you that you could put a big pan of cinnamon rolls together in about the same amount of time it takes for your oven to heat? With just seven ingredients (all staples you can keep in your pantry and fridge), you can make fragrant iced cinnamon rolls without a stand mixer, prolonged kneading, or rising time. Let’s make this magic happen!
Boston has a truly wonderful coffee scene, full of no-nonsense spots with good, strong coffee as well as impeccably designed Insta-worthy cafes with delicious brunch spreads. The best ones, however, have all of the above. Every neighborhood in Boston boasts its own renowned coffee shop, so much so that you could potentially get to know Boston just by bouncing from coffee shop to coffee shop. Here are my five favorite coffee shops, with good coffee, cozy atmospheres, and amazing interiors.
For now classes are 6pm and 640pm at 2840 Wildwood st in the Boise Cloggers studio.
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Warriors Fit Audio
Warrior Fit uses High Intensity Music to get ya Moooovin' So we can all "Get Our Sweat On"
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RESEARCH OF THE WEEK
For now classes are 6pm and 640pm at 2840 Wildwood st in the Boise Cloggers studio.
Book your class NOW!
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Me 'n Wilson
