I ranted a little about diet approach, leptin and the set-point theory on bodybuilding.com. Figured it could make for a decent post here. I added some extras in the form of a short review on the effects of intermittent fasting on leptin.

Short background on leptin and set-pointLeptin is a master-hormone with downstream effects on other hormones related to metabolism (T3/T4, neuropeptide-Y, epinephrine, among many others).
In the short term leptin is regulated by under-and overfeeding. More to the point, anything that causes fat mobilization from adipose tissues will drop leptin; this is basically unavoidable.
In the long-term, leptin is regulated by total amount of fat mass. A drop in leptin affects the other hormones negatively and vice versa. Low leptin equals an increase in hunger and metabolic rate, much like high leptin equals a decrease in hunger and increase in metabolic rate.
Generally speaking, lean people have low levels of leptin while obese […]

Original post by noreply@blogger.com (Martin Berkhan)

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