Do Statins Reduce Small, Dense LDL? Fasting Sure Does

February 7, 2011

I came across an interesting statin study the other day. It’s from last year, but I hadn’t seen it until recently. The study, entitled “Statins Do Not Decrease Small, Dense Low Density-Lipoprotein,” sought to understand the effect of statin therapy on small, dense LDL, the truly “bad” kind of “bad” cholesterol, the stuff that’s strongly associated with increased heart disease risk in many studies. We know that statins reduce LDL cholesterol – they are extremely effective at curtailing the cholesterol-synthesizing hydroxy-methyl-glutaryl-coenzyme A reductase, if you’re into that sort of thing – but their effectiveness at lowering sdLDL is unknown. They reduce the rate at which cholesterol is produced and that’s as specific as it gets.

Researchers at the Cardiovascular Center of Korea University’s Guro Hospital assembled a group of 612 heart patients, some with confirmed coronary artery disease (CAD) but most without. They were divided into two groups on the basis […]

Original post by Mark Sisson

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